Corcumin or corcuma is the scientific name of the ancient spice turmeric. It is a rhizome that is commonly available in the market as a bright yellow powder. It is a popular condiment and culinary dye in the East and the Mid-East. However, other than its utility in the kitchen, corcumin also has medical uses. It is a mild digestive and an antiseptic, and currently, it is regarded as a cure for cystic fibrosis (The Epicentre, 2003). What are the major symptoms of cystic fibrosis?
Cystic Fibrosis is often diagnosed from symptoms characterized by thick, viscious mucus secreations in the lungs, color and amount change of sputum, chronic cough usually with blood streaks, wheezing, and bronchitis. Other symptoms of the disease include chronic sinusitis, asthma, nasal polyps, weight loss, dehydration, excessive salt in sweat, abdominal pain, flatulence, and fatigue (The Epicentre, 2003). Why does the sweat of patients with CF have excess salt? The sweat of CF patients have excessive salt because the CF blocks the chloride that passes through the membranes.
This leaves the chloride stranded in the sweat ducts, resulting in trapped sodium and positively charged chloride. This causes the salty seat that emerges from the body of a CF patient (Orenstein, 2003). What is CFTR and what is its normal function? Also known as cystic fibrosis transmembrane conductance regulator, CFTR is responsible for making protein that serves as a channel for the membrane of cells that produce mucus, sweat, saliva, tears, and digestive enzymes.
It helps in the transportation of positive chloride ions and negative sodium ions. It also regulates the movement of water in the tissues, which is necessary for the production of thin, free-flowing mucus. This mucus lubricates the linings of the different body systems (National Library of Medicine [NLM], 2009). What is the role of cAMP in CFTR function? The role of cyclic adenosine monophosphate in CFTR function is that it helps regulate the CFTR through protein kinase A (NLM, 2009).
Why does delta F508 mutation in CFTR cause CF? How is the delta F508 protein different from normal proteins? How does this change affect the movement of the protein through the ER? Delta F508 protein mutation causes CF because it lacks phenylalanine residue at position 508. Due to this, it cannot function as normal proteins do. When this mutation is synthesized through the normal cellular machinery, it is rapidly recognized as misfolded and is shortly degraded even before reaching the actual site of action at the cell surface.
There is only a low probability for this kind of protein mutation to reach the ER or the endoplasmic reticulum (Rowe, Miller, & Sorscher, 2005). References National Library of Medicine. (2009, May 29). “CFTR”. Genetics Home Reference. Retrived June 3, 2009, from http://ghr. nlm. nih. gov/gene=cftr Orenstein, D. (2003). Cystic Fibrosis. New York: Lippincott Williams & Wilkins. Rowe, S. M. , Miller, S. , & Sorscher, E. J. (2005). Cystic fibrosis. New England Journal of Medicine, 352 (19), 1992–2001. The Epicentre. (2003). Turmeric. The Epicentre Encyclopedia of Spices. R
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